Mephenteramine is not used to provide induced hypotension during surgery

023. Which of the following agents is not used to provide induced hypotension during surgery?

1. Sodium nitroprusside

2. Hydralazine

3. Mephenteramine

4. Esmolol

Answer

3. Mephenteramine

Reference

KDTripathi,4^th Edition Page 112

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Discussion

Mephentermine (Wyamine)

Brand names

Mephentine

Category:

• Adrenergic Drug

Description:

• Antihypotensive

Indications:

• Hypotension during spinal anesthesia

Contraindications:

• Hypotension induced by chlorpromazine
• Concurrent use with any MAOI

Precautions:

• Pregnancy category C
• Cardiovascular disease, chronically ill patients
• Hemorrhagic shock, hyperthyroidism, hypertension

Explanation

Sodium nitroprusside, hydralazine and esmolol are used to produce hypotension while mephentermine is used to protect against hypotension

Comments

Dosage:

Administered intramuscularly, intravenously

• Adult:
• Prevention of hypotension during spinal anesthesia:
• IM 30-45mg 10-20 minutes prior to anesthesia
• Hypotension following spinal anesthesia:
• IV 30-45mg, repeat doses of 30mg as needed to maintain blood pressure
• IV INF use 0.1%

Tips

Adverse Reactions (Side Effects):

• CNS: anxiety, confusion, drowsiness, incoherence, tremors
• CV: hypertension, palpitations, tachydardia