The following are trypsin inhibitors alpha - 1 Anti trypsin alpha-1-anti proteinase Egg-white

Question 34

The following are trypsin inhibitors except..

a.       alpha - 1 Anti trypsin

b.      alpha-1-anti proteinase

c.       Enterokinase

d.      Egg-white

Answer

c. ENterokinase

Reference:

Harper 27^th Edition Page 597

Chaterjee 6^th Edition Page 398

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Discussion

Trypsin is a proteinase. And can hydrolyze a peptide bond formed by the carbonyl group of a lysine residue on trypsinogen, converting the latter to trypsin and inactive hexapeptide

Explanation

a.       alpha - 1 Anti trypsin is the principal serine protease inhibitor of human plasma. It inhibits trypsin, elastase and certain other proteases forming complexes with them.

b.      alpha-1-anti proteinase is the new name for alpha - 1 Anti trypsin

c.       Enterokinase activates trypsinogen into trypsin in the presence of Calcium

d.      Egg-white is a trypsin inhibitor

Comments

Other trypsin inhibitors are

·        Human and bovin Colostrum

·        Raw SOyabeans

·        DFP (Di Iso propyl fluoro phosphate

Tips

Trypsin can be activated (ie trypsinogen converted to trypsin) by

·        Enterokinase

·        Trypsin itself (Autocatalytically)